Your neurologist will start CEBRIUS (Cenobamate) at a low dose of 12.5 mg once daily and gradually increase the dose following a carefully designed titration schedule. This gradual approach is important for safety and tolerability.
| Week | Daily Dose |
|---|---|
| Weeks 1–2 | 12.5 mg once daily |
| Weeks 3–4 | 25 mg once daily |
| Weeks 5–6 | 50 mg once daily |
| Weeks 7–8 | 100 mg once daily |
| Weeks 9–10 | 150 mg once daily |
| Weeks 11+ (Maintenance) | 200 mg once daily (max 400 mg/day, based on response) |
CEBRIUS is indicated for the treatment of focal-onset seizures in adults. It may be prescribed alone or alongside other anti-seizure medicines, depending on your individual treatment plan. ,
Every patient is different. Your healthcare provider will work with you to find the dose that provides the best seizure control while maintaining tolerability.
Once Daily — CEBRIUS is taken once daily, with or without food.
Take It Consistently — Taking your medicine at the same time each day may help you stay on track with your treatment plan.
Contact your healthcare provider if:
If you happen to miss a dose of CEBRIUS, just take your next day's dose as you normally would to get back on track — don't double up. Do not change your dose or restart treatment on your own without medical advice.
Every seizure-free day matters. With consistent treatment and ongoing communication with your healthcare team, you can work toward better seizure control and greater confidence in everyday life.